Banca de DEFESA: Jackson Henrique Emmanuel de Santana

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : Jackson Henrique Emmanuel de Santana
DATE: 19/01/2024
TIME: 08:00
LOCAL: Ambiente Teams do PPGMT
TITLE:

Life and death of Cryptococcus neoformans when taken up by murine macrophages

KEY WORDS:

Cryptococcus neoformans, Virulence, Trojan Horse, Immune Response.

PAGES: 54
BIG AREA: Ciências Biológicas
AREA: Microbiologia
SUBÁREA: Biologia e Fisiologia dos Microorganismos
SPECIALTY: Micologia
SUMMARY:

The infection caused by Cryptococcus neoformans has a global
relevance, being set as the main cause of fungal meningitis around the world.
The cryptococcosis mainly affects immunocompromised individuals, such as
people with AIDS, but can also grieve healthy people, even in a rare rate.
The evasion and virulence mechanisms of the fungus makes it possible to
trespass the blood-brain barrier and cause inflammation of the cerebral
meninges. One of these mechanisms is called Trojan Horse, this mechanism
allows the fungus to infect and survive inside host immune cells, migrating to
the brain inside those cells while it’s protected against the immune response
of the host. To better understand how C. neoformans dies and survive when it
is phagocytosed by macrophages, we designed an innovative assay which
aims to document, through fluorescence markers, the death and survival of
the fungus when interacting with J774 macrophages.

COMMITTEE MEMBERS:
Presidente - 2346559 - HUGO COSTA PAES
Interna - 2095134 - PATRICIA ALBUQUERQUE DE ANDRADE NICOLA
Externa ao Programa - 1657325 - LARISSA FERNANDES MATOS - UnBExterna à Instituição - ROSÂNGELA VIEIRA DE ANDRADE - UCB