Banca de DEFESA: Jéssica Luana Sousa da Costa

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : Jéssica Luana Sousa da Costa
DATE: 14/02/2024
TIME: 14:00
LOCAL: Sala virtual do Teams
TITLE:

DETECTION OF SUBCLINICAL LEPROSY IN PATIENTS IN THERAPY WITH IMMUNOSUPPRESSANT DRUGS AND IMMUNUBIOLOGICALS IN THE FEDERAL DISTRICT

KEY WORDS:

Leprosy; Immunology of leprosy; Autoimmune disease; Immunosuppressants; Psoriasis; Pemphigus

PAGES: 59
BIG AREA: Ciências da Saúde
AREA: Medicina
SUBÁREA: Clínica Médica
SPECIALTY: Doenças Infecciosas e Parasitárias
SUMMARY:

Introduction: Leprosy is a chronic infectious disease that causes neurological and dermatological manifestations. The host's immune response against M. leprae is a crucial factor in the clinical manifestation of the disease. Patients with autoimmune diseases are characterized by a malfunctioning immune system, leading the body to mistakenly attack its own healthy cells. Consequently, numerous immunosuppressants and immunobiologics have been developed to block or regulate the undesired immune response. However, this blockade may render patients more susceptible to infectious diseases. Objectives: To assess the frequency of subclinical or asymptomatic leprosy in patients with autoimmune diseases undergoing treatment with immunosuppressants and immunobiologics and to evaluate the effectiveness of the Bioclin Fast ML Flow kit for this detection. Materials and Methods: The study utilized samples collected at the University Hospital of Brasília, involving patients with autoimmune conditions such as psoriasis and pemphigus, undergoing maintenance therapy with immunosuppressive and immunobiologic drugs. Blood samples were collected to obtain serum for the Fast ML Flow Leprosy test. Clinical data were retrieved from medical records. Results: 44 patients were analyzed, with an average age of 52 ±13.7 years, and 59% of the sample population was female. Psoriasis was the predominant autoimmune disease, accounting for 82%. Two male patients with psoriasis tested positive for the Fast ML Flow Leprosy test. These patients were using adalimumab and secukinumab. Conclusion: Based on the findings of this study, the ML Flow Leprosy test is a rapid, less invasive tool that proves to be useful for screening subclinical or asymptomatic leprosy in patients with autoimmune diseases.

COMMITTEE MEMBERS:
Presidente - 2646005 - AMILCAR SABINO DAMAZO
Interno - 1553559 - JOSE ROBERTO DE SOUZA DE ALMEIDA LEITE
Externa à Instituição - VANINA DANUZA TOSO - UFMT